Publications

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  1. Ross RA, Leon S, Madara JC, Schafer D, Fergani C, et al. PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse. Elife. 2018 Jun 15;7: pii: e35960. PubMed PMID 29905528; PubMed Central PMCID PMC6013253.
  2. Maguire CA, León S, Carroll RS, Kaiser UB, Navarro VM. Altered circadian feeding behavior and improvement of metabolic syndrome in obese Tac1-deficient mice. International Journal of Obesity. 2017 Dec;41(12):1798-1804. PubMed PMID 28775376; PubMed Central PMCID PMC5716839
  3. Maguire CA, Song YB, Wu M, Leon S, Carroll RS, Alreja M, Kaiser UB, Navarro VM. Tac 1 Signaling is Required for Sexual Maturation and Responsiveness on GnRH Neurons to Kisspeptin in the Male Mouse. Endocrinology. 2017 Jul 1;158(7):2319-2329. PubMed PMID 28444173; PubMed Central PMCID PMC5505212
  4. Fergani C, Navarro V. Expanding the Role of Tachykinins in the Neuroendocrine Control of Reproduction. Reproduction. 2016 Nov 15; 153(1):R1-14. PubMed PMID: 27754872
  5. Lewis EI, Maguire CA, Carroll RS, Kaiser UB, Navarro VM. The role of Tac1 neurons in the metabolic and reproductive action of leptin. Fertility and Sterility. 2016 Sept 1;106(3):e266.
  6. Babwah AV, Navarro VM, Ahow M, Pampillo M, Nash C, et al. GnRH neuron-specific ablation of Gαq/11 results in only partial inactivation of the Neuroendocrine-reproductive Axis in both male and female mice: in vivo evidence for Kiss1r-coupled Gαq/11-independent GnRH secretion. Journal of Neuroscience. 2015 Sept 16;35 (37) 12903-16. PubMed PMID: 26377475; PubMed Central PMCID: PMC4571609.
  7. Simavli S, Thompson IR, Maguire CA, Gill JC, Carroll RS, Kaiser UB, Navarro VM. Substance P Regulates Puberty Onset and Fertility in the Female Mouse. Endocrinology. 2015 Apr 9;PubMed PMID: 25856429.
  8. Yamamura T, Wakabayashi Y, Ohkura S, Navarro VM, Okamura H. Effects of intravenous administration of neurokinin receptor subtype-selective agonists on gonadotropin-releasing hormone pulse generator activity and luteinizing hormone secretion in goats. J Reprod Dev. 2015 Feb 24;61(1):20-9. PubMed PMID: 25345909; PubMed Central PMCID: PMC4354227.
  9. Navarro VM, Bosch MA, León S, Simavli S, True C, et al. The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Endocrinology. 2015 Feb;156(2):627-37. PubMed PMID: 25422875; PubMed Central PMCID: PMC4298326.
  10. Ruiz-Pino F, Garcia-Galiano D, Manfredi-Lozano M, Leon S, Sánchez-Garrido MA, et al. Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats. Endocrinology. 2015 Feb;156(2):576-88. PubMed PMID: 25490143; PubMed Central PMCID: PMC4298329.
  11. Martin C, Navarro VM, Simavli S, Vong L, Carroll RS, et al. Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone. J Neurosci. 2014 Apr 23;34(17):6047-56. PubMed PMID: 24760864; PubMed Central PMCID: PMC3996222.
  12. Navarro VM, Kaiser UB. Metabolic influences on neuroendocrine regulation of reproduction. Curr Opin Endocrinol Diabetes Obes. 2013 Aug;20(4):335-41. PubMed PMID: 23807606; NIHMSID: NIHMS535893; PubMed Central PMCID: PMC3898855.
  13. Popa SM, Moriyama RM, Caligioni CS, Yang JJ, Cho CM, et al. Redundancy in Kiss1 expression safeguards reproduction in the mouse. Endocrinology. 2013 Aug;154(8):2784-94. PubMed PMID: 23736293; PubMed Central PMCID: PMC3713212.
  14. Abreu AP, Dauber A, Macedo DB, Noel SD, Brito VN, et al. Central precocious puberty caused by mutations in the imprinted gene MKRN3. N Engl J Med. 2013 Jun 27;368(26):2467-75. PubMed PMID: 23738509; NIHMSID: NIHMS503884; PubMed Central PMCID: PMC3808195.
  15. Sangiao-Alvarellos S, Manfredi-Lozano M, Ruiz-Pino F, Navarro VM, Sánchez-Garrido MA, et al. Changes in hypothalamic expression of the Lin28/let-7 system and related microRNAs during postnatal maturation and after experimental manipulations of puberty. Endocrinology. 2013 Feb;154(2):942-55. PubMed PMID: 23291449; PubMed Central PMCID: PMC3548186.
  16. Navarro VM. Interactions between kisspeptins and neurokinin B. Adv Exp Med Biol. 2013;784:325-47. PubMed PMID: 23550013; NIHMSID: NIHMS534249; PubMed Central PMCID: PMC3858905.
  17. García-Galiano D, Pineda R, Roa J, Ruiz-Pino F, Sánchez-Garrido MA, et al. Differential modulation of gonadotropin responses to kisspeptin by aminoacidergic, peptidergic, and nitric oxide neurotransmission. Am J Physiol Endocrinol Metab. 2012 Nov 15;303(10):E1252-63. PubMed PMID: 23011064.
  18. Gill JC, Navarro VM, Kwong C, Noel SD, Martin C, et al. Increased neurokinin B (Tac2) expression in the mouse arcuate nucleus is an early marker of pubertal onset with differential sensitivity to sex steroid-negative feedback than Kiss1. Endocrinology. 2012 Oct;153(10):4883-93. PubMed PMID: 22893725; PubMed Central PMCID: PMC3512019.
  19. Ruiz-Pino F, Navarro VM, Bentsen AH, Garcia-Galiano D, Sanchez-Garrido MA, et al. Neurokinin B and the control of the gonadotropic axis in the rat: developmental changes, sexual dimorphism, and regulation by gonadal steroids. Endocrinology. 2012 Oct;153(10):4818-29. PubMed PMID: 22822161; PubMed Central PMCID: PMC3512006.
  20. Steiner RA, Navarro VM. Tacking toward reconciliation on Tacr3/TACR3 mutations. Endocrinology. 2012 Apr;153(4):1578-81. PubMed PMID: 22408179; PubMed Central PMCID: PMC3320245.
  21. Navarro VM, Ruiz-Pino F, Sánchez-Garrido MA, García-Galiano D, Hobbs SJ, et al. Role of neurokinin B in the control of female puberty and its modulation by metabolic status. J Neurosci. 2012 Feb 15;32(7):2388-97. PubMed PMID: 22396413; NIHMSID: NIHMS356850; PubMed Central PMCID: PMC3567461.
  22. Navarro VM. New insights into the control of pulsatile GnRH release: the role of Kiss1/neurokinin B neurons. Front Endocrinol (Lausanne). 2012;3:48. PubMed PMID: 22649420; PubMed Central PMCID: PMC3355984.
  23. García-Galiano D, van Ingen Schenau D, Leon S, Krajnc-Franken MA, Manfredi-Lozano M, et al. Kisspeptin signaling is indispensable for neurokinin B, but not glutamate, stimulation of gonadotropin secretion in mice. Endocrinology. 2012 Jan;153(1):316-28. PubMed PMID: 22067321.
  24. Navarro VM, Gottsch ML, Wu M, García-Galiano D, Hobbs SJ, et al. Regulation of NKB pathways and their roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouse. Endocrinology. 2011 Nov;152(11):4265-75. PubMed PMID: 21914775; PubMed Central PMCID: PMC3198996.
  25. Roa J, Navarro VM, Tena-Sempere M. Kisspeptins in reproductive biology: consensus knowledge and recent developments. Biol Reprod. 2011 Oct;85(4):650-60. PubMed PMID: 21677307.
  26. Navarro VM, Tena-Sempere M. Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility. Nat Rev Endocrinol. 2011 Sep 13;8(1):40-53. PubMed PMID: 21912400.
  27. Luque RM, Córdoba-Chacón J, Gahete MD, Navarro VM, Tena-Sempere M, et al. Kisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanisms. Endocrinology. 2011 Mar;152(3):957-66. PubMed PMID: 21209013; PubMed Central PMCID: PMC3198963.
  28. Navarro VM, Tena-Sempere M. Kisspeptins and the neuroendocrine control of reproduction. Front Biosci (Schol Ed). 2011 Jan 1;3:267-75. PubMed PMID: 21196375.
  29. Navarro VM, Castellano JM, McConkey SM, Pineda R, Ruiz-Pino F, et al. Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat. Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E202-10. PubMed PMID: 21045176; PubMed Central PMCID: PMC3774070.
  30. García-Galiano D, Navarro VM, Gaytan F, Tena-Sempere M. Expanding roles of NUCB2/nesfatin-1 in neuroendocrine regulation. J Mol Endocrinol. 2010 Nov;45(5):281-90. PubMed PMID: 20682642.
  31. García-Galiano D, Navarro VM, Roa J, Ruiz-Pino F, Sánchez-Garrido MA, et al. The anorexigenic neuropeptide, nesfatin-1, is indispensable for normal puberty onset in the female rat. J Neurosci. 2010 Jun 9;30(23):7783-92. PubMed PMID: 20534827.
  32. Wakabayashi Y, Nakada T, Murata K, Ohkura S, Mogi K, et al. Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat. J Neurosci. 2010 Feb 24;30(8):3124-32. PubMed PMID: 20181609.
  33. Dungan Lemko HM, Naderi R, Adjan V, Jennes LH, Navarro VM, et al. Interactions between neurotensin and GnRH neurons in the positive feedback control of GnRH/LH secretion in the mouse. Am J Physiol Endocrinol Metab. 2010 Jan;298(1):E80-8. PubMed PMID: 19861584; PubMed Central PMCID: PMC2806107.
  34. Kauffman AS, Navarro VM, Kim J, Clifton DK, Steiner RA. Sex differences in the regulation of Kiss1/NKB neurons in juvenile mice: implications for the timing of puberty. Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1212-21. PubMed PMID: 19755669; PubMed Central PMCID: PMC2781353.
  35. Navarro VM, Gottsch ML, Chavkin C, Okamura H, Clifton DK, et al. Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. J Neurosci. 2009 Sep 23;29(38):11859-66. PubMed PMID: 19776272; NIHMSID: NIHMS155870; PubMed Central PMCID: PMC2793332.
  36. Gottsch ML, Navarro VM, Zhao Z, Glidewell-Kenney C, Weiss J, et al. Regulation of Kiss1 and dynorphin gene expression in the murine brain by classical and nonclassical estrogen receptor pathways. J Neurosci. 2009 Jul 22;29(29):9390-5. PubMed PMID: 19625529; NIHMSID: NIHMS171606; PubMed Central PMCID: PMC2819182.
  37. Navarro VM, Sánchez-Garrido MA, Castellano JM, Roa J, García-Galiano D, et al. Persistent impairment of hypothalamic KiSS-1 system after exposures to estrogenic compounds at critical periods of brain sex differentiation. Endocrinology. 2009 May;150(5):2359-67. PubMed PMID: 19106226.
  38. Castellano JM, Navarro VM, Roa J, Pineda R, Sánchez-Garrido MA, et al. Alterations in hypothalamic KiSS-1 system in experimental diabetes: early changes and functional consequences. Endocrinology. 2009 Feb;150(2):784-94. PubMed PMID: 18845637.
  39. Roa J, Castellano JM, Navarro VM, Handelsman DJ, Pinilla L, et al. Kisspeptins and the control of gonadotropin secretion in male and female rodents. Peptides. 2009 Jan;30(1):57-66. PubMed PMID: 18793689.
  40. Roa J, Vigo E, Castellano JM, Gaytan F, García-Galiano D, et al. Follicle-stimulating hormone responses to kisspeptin in the female rat at the preovulatory period: modulation by estrogen and progesterone receptors. Endocrinology. 2008 Nov;149(11):5783-90. PubMed PMID: 18635654.
  41. Roa J, Vigo E, García-Galiano D, Castellano JM, Navarro VM, et al. Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states. Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1088-96. PubMed PMID: 18413669.
  42. Roa J, Vigo E, Castellano JM, Gaytan F, Navarro VM, et al. Opposite roles of estrogen receptor (ER)-alpha and ERbeta in the modulation of luteinizing hormone responses to kisspeptin in the female rat: implications for the generation of the preovulatory surge. Endocrinology. 2008 Apr;149(4):1627-37. PubMed PMID: 18174277.
  43. Navarro VM, Tena-Sempere M. The KiSS-1/GPR54 system: putative target for endocrine disruption of reproduction at hypothalamic-pituitary unit?. Int J Androl. 2008 Apr;31(2):224-32. PubMed PMID: 17971159.
  44. Vigo E, Roa J, Pineda R, Castellano JM, Navarro VM, et al. Novel role of the anorexigenic peptide neuromedin U in the control of LH secretion and its regulation by gonadal hormones and photoperiod. Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1265-73. PubMed PMID: 17726140.
  45. Fernández-Fernández R, Tena-Sempere M, Roa J, Castellano JM, Navarro VM, et al. Direct stimulatory effect of ghrelin on pituitary release of LH through a nitric oxide-dependent mechanism that is modulated by estrogen. Reproduction. 2007 Jun;133(6):1223-32. PubMed PMID: 17636176.
  46. Navarro VM, Castellano JM, García-Galiano D, Tena-Sempere M. Neuroendocrine factors in the initiation of puberty: the emergent role of kisspeptin. Rev Endocr Metab Disord. 2007 Mar;8(1):11-20. PubMed PMID: 17340172.
  47. Vigo E, Roa J, López M, Castellano JM, Fernandez-Fernandez R, et al. Neuromedin s as novel putative regulator of luteinizing hormone secretion. Endocrinology. 2007 Feb;148(2):813-23. PubMed PMID: 17110433.
  48. Castellano JM, Navarro VM, Fernández-Fernández R, Roa J, Vigo E, et al. Effects of galanin-like peptide on luteinizing hormone secretion in the rat: sexually dimorphic responses and enhanced sensitivity at male puberty. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1281-9. PubMed PMID: 16849629.
  49. Castellano JM, Gaytan M, Roa J, Vigo E, Navarro VM, et al. Expression of KiSS-1 in rat ovary: putative local regulator of ovulation?. Endocrinology. 2006 Oct;147(10):4852-62. PubMed PMID: 16825322.
  50. Castellano JM, Navarro VM, Fernández-Fernández R, Castaño JP, Malagón MM, et al. Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat. Mol Cell Endocrinol. 2006 Sep 26;257-258:75-83. PubMed PMID: 16930819.
  51. Castellano JM, Navarro VM, Fernández-Fernández R, Roa J, Vigo E, et al. Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. Diabetes. 2006 Sep;55(9):2602-10. PubMed PMID: 16936210.
  52. Fernandez-Fernandez R, Martini AC, Navarro VM, Castellano JM, Dieguez C, et al. Novel signals for the integration of energy balance and reproduction. Mol Cell Endocrinol. 2006 Jul 25;254-255:127-32. PubMed PMID: 16759792.
  53. Roa J, Vigo E, Castellano JM, Navarro VM, Fernández-Fernández R, et al. Hypothalamic expression of KiSS-1 system and gonadotropin-releasing effects of kisspeptin in different reproductive states of the female Rat. Endocrinology. 2006 Jun;147(6):2864-78. PubMed PMID: 16527840.
  54. Tovar S, Vázquez MJ, Navarro VM, Fernández-Fernández R, Castellano JM, et al. Effects of single or repeated intravenous administration of kisspeptin upon dynamic LH secretion in conscious male rats. Endocrinology. 2006 Jun;147(6):2696-704. PubMed PMID: 16513831.
  55. Pinilla L, Fernández-Fernández R, Vigo E, Navarro VM, Roa J, et al. Stimulatory effect of PYY-(3-36) on gonadotropin secretion is potentiated in fasted rats. Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1162-71. PubMed PMID: 16390861.
  56. Navarro VM, Fernández-Fernández R, Nogueiras R, Vigo E, Tovar S, et al. Novel role of 26RFa, a hypothalamic RFamide orexigenic peptide, as putative regulator of the gonadotropic axis. J Physiol. 2006 May 15;573(Pt 1):237-49. PubMed PMID: 16543265; PubMed Central PMCID: PMC1779712.
  57. Martini AC, Fernández-Fernández R, Tovar S, Navarro VM, Vigo E, et al. Comparative analysis of the effects of ghrelin and unacylated ghrelin on luteinizing hormone secretion in male rats. Endocrinology. 2006 May;147(5):2374-82. PubMed PMID: 16455774.
  58. Leffers H, Navarro VM, Nielsen JE, Mayen A, Pinilla L, et al. Increased expression of alpha- and beta-globin mRNAs at the pituitary following exposure to estrogen during the critical period of neonatal sex differentiation in the rat. J Steroid Biochem Mol Biol. 2006 Apr;99(1):33-43. PubMed PMID: 16520034.
  59. Sánchez-Criado JE, de Las Mulas JM, Bellido C, Navarro VM, Aguilar R, et al. Gonadotropin-secreting cells in ovariectomized rats treated with different oestrogen receptor ligands: a modulatory role for ERbeta in the gonadotrope?. J Endocrinol. 2006 Feb;188(2):167-77. PubMed PMID: 16461544.
  60. Castellano JM, Navarro VM, Fernández-Fernández R, Nogueiras R, Tovar S, et al. Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition. Endocrinology. 2005 Sep;146(9):3917-25. PubMed PMID: 15932928.
  61. Fernández-Fernández R, Navarro VM, Barreiro ML, Vigo EM, Tovar S, et al. Effects of chronic hyperghrelinemia on puberty onset and pregnancy outcome in the rat. Endocrinology. 2005 Jul;146(7):3018-25. PubMed PMID: 15790726.
  62. Navarro VM, Castellano JM, Fernández-Fernández R, Tovar S, Roa J, et al. Effects of KiSS-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat. Endocrinology. 2005 Apr;146(4):1689-97. PubMed PMID: 15637288.
  63. Fernández-Fernández R, Tena-Sempere M, Navarro VM, Barreiro ML, Castellano JM, et al. Effects of ghrelin upon gonadotropin-releasing hormone and gonadotropin secretion in adult female rats: in vivo and in vitro studies. Neuroendocrinology. 2005;82(5-6):245-55. PubMed PMID: 16721030.
  64. Navarro VM, Castellano JM, Fernández-Fernández R, Tovar S, Roa J, et al. Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54. Endocrinology. 2005 Jan;146(1):156-63. PubMed PMID: 15375028.
  65. Navarro VM, Fernández-Fernández R, Castellano JM, Roa J, Mayen A, et al. Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54. J Physiol. 2004 Dec 1;561(Pt 2):379-86. PubMed PMID: 15486019; PubMed Central PMCID: PMC1665361.
  66. Navarro VM, Castellano JM, Fernández-Fernández R, Barreiro ML, Roa J, et al. Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide. Endocrinology. 2004 Oct;145(10):4565-74. PubMed PMID: 15242985.
  67. Nogueiras R, Barreiro ML, Caminos JE, Gaytán F, Suominen JS, et al. Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factors. J Cell Sci. 2004 Jul 1;117(Pt 15):3247-57. PubMed PMID: 15226398.
  68. Barreiro ML, Pineda R, Navarro VM, Lopez M, Suominen JS, et al. Orexin 1 receptor messenger ribonucleic acid expression and stimulation of testosterone secretion by orexin-A in rat testis. Endocrinology. 2004 May;145(5):2297-306. PubMed PMID: 14764632.
  69. Tena-Sempere M, Navarro VM, Mayen A, Bellido C, Sánchez-Criado JE. Regulation of estrogen receptor (ER) isoform messenger RNA expression by different ER ligands in female rat pituitary. Biol Reprod. 2004 Mar;70(3):671-8. PubMed PMID: 14613904.